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IDH2
Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex. Belongs to the isocitrate and isopropylmalate dehydrogenases family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.1.1.42; Mitochondrial; Other Amino Acids Metabolism - glutathione; Oxidoreductase |
| Chromosomal Location of human Ortholog: 15q26.1 |
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Cellular Component:
cytosol; mitochondrial matrix; mitochondrion; peroxisome
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Molecular Function:
isocitrate dehydrogenase (NADP+) activity; magnesium ion binding; NAD binding
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Biological Process:
2-oxoglutarate metabolic process; carbohydrate metabolic process; glyoxylate cycle; isocitrate metabolic process; NADP metabolic process; tricarboxylic acid cycle
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Disease: D-2-hydroxyglutaric Aciduria 2
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Reference #:
P48735
(UniProtKB)
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Alt. Names/Synonyms: D2HGA2; ICD-M; IDH; IDH2; IDHM; IDHP; IDP; IDPM; isocitrate dehydrogenase (NADP(+)) 2; isocitrate dehydrogenase (NADP(+)) 2, mitochondrial; isocitrate dehydrogenase 2 (NADP+), mitochondrial; Isocitrate dehydrogenase [NADP], mitochondrial; isocitrate dehydrogenase, mitochondrial; mNADP-IDH; NADP(+)-specific ICDH; NADP+-specific ICDH; Oxalosuccinate decarboxylase
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Gene Symbols: IDH2
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Molecular weight:
50,909 Da
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Basal Isoelectric point:
8.88
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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