ATP10D Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. Expressed in placenta and, to a lesser extent, in kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of mouse Ortholog: 5|5 C3.2
Cellular Component:  endoplasmic reticulum; membrane; nucleoplasm; phospholipid-translocating ATPase complex; plasma membrane
Molecular Function:  ATP binding; ATPase-coupled intramembrane lipid transporter activity; glycosylceramide flippase activity; magnesium ion binding
Biological Process:  monoatomic cation transport; phospholipid translocation
Reference #:  Q8K2X1 (UniProtKB)
Alt. Names/Synonyms: 9830145H18Rik; AT10D; Atp10d; ATPase class V type 10D; ATPase, class V, type 10D; ATPVD; D5Buc24e; MGC37731; P4-ATPase flippase complex alpha subunit ATP10D; Phospholipid-transporting ATPase VD; Probable phospholipid-transporting ATPase VD; putative type IV aminophospholipid transporting ATPase
Gene Symbols: Atp10d
Molecular weight: 158,330 Da
Basal Isoelectric point: 6.58  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene