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ATP10D
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. Expressed in placenta and, to a lesser extent, in kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.6.3.1; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel |
| Chromosomal Location of mouse Ortholog: 5|5 C3.2 |
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Cellular Component:
plasma membrane
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Molecular Function:
ATPase-coupled intramembrane lipid transporter activity
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Biological Process:
phospholipid translocation
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Reference #:
Q8K2X1
(UniProtKB)
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Alt. Names/Synonyms: 9830145H18Rik; AT10D; Atp10d; ATPase class V type 10D; ATPase, class V, type 10D; ATPVD; D5Buc24e; MGC37731; P4-ATPase flippase complex alpha subunit ATP10D; Probable phospholipid-transporting ATPase VD; putative type IV aminophospholipid transporting ATPase
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Gene Symbols: Atp10d
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Molecular weight:
158,330 Da
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Basal Isoelectric point:
6.58
Predict pI for various phosphorylation states
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