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PPHLN1
Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin. Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex. The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed. May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal; RNA-binding |
| Chromosomal Location of human Ortholog: 12q12 |
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Cellular Component:
chromosome; cytosol; Golgi apparatus; nucleoplasm
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Molecular Function:
protein binding
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Biological Process:
keratinization; negative regulation of DNA-templated transcription; negative regulation of gene expression, epigenetic; positive regulation of DNA methylation-dependent heterochromatin formation; protein localization to heterochromatin
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Reference #:
Q8NEY8
(UniProtKB)
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Alt. Names/Synonyms: CDC7 expression repressor; CR; Gastric cancer antigen Ga50; HSPC206; HSPC232; MGC48786; periphilin 1; Periphilin-1; PPHLN; PPHLN1
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Gene Symbols: PPHLN1
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Molecular weight:
52,737 Da
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Basal Isoelectric point:
9.15
Predict pI for various phosphorylation states
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