PYGL Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. Belongs to the glycogen phosphorylase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - starch and sucrose; EC; Transferase
Chromosomal Location of human Ortholog: 14q22.1
Cellular Component:  cytosol; extracellular region; ficolin-1-rich granule lumen; secretory granule lumen
Molecular Function:  AMP binding; ATP binding; bile acid binding; drug binding; glucose binding; glycogen phosphorylase activity; linear malto-oligosaccharide phosphorylase activity; protein binding; protein homodimerization activity; purine nucleobase binding; SHG alpha-glucan phosphorylase activity; vitamin binding
Biological Process:  5-phosphoribose 1-diphosphate biosynthetic process; glucose homeostasis; glycogen catabolic process; glycogen metabolic process; necroptotic process; neutrophil degranulation; response to bacterium
Disease: Glycogen Storage Disease Vi
Reference #:  P06737 (UniProtKB)
Alt. Names/Synonyms: glycogen phosphorylase L; Glycogen phosphorylase, liver form; GSD6; phosphorylase, glycogen, liver; PYGL
Gene Symbols: PYGL
Molecular weight: 97,149 Da
Basal Isoelectric point: 6.71  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein