MTHFD1 In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family. Ubiquitous. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - glyoxylate and dicarboxylate; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 1.5.1.5; EC 3.5.4.9; EC 6.3.4.3; Hydrolase; Ligase; Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: 14q23.3
Cellular Component:  cytosol; mitochondrion
Molecular Function:  ATP binding; formate-tetrahydrofolate ligase activity; methenyltetrahydrofolate cyclohydrolase activity; methylenetetrahydrofolate dehydrogenase (NAD+) activity; methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity; protein binding
Biological Process:  10-formyltetrahydrofolate biosynthetic process; embryonic neurocranium morphogenesis; embryonic viscerocranium morphogenesis; folic acid metabolic process; heart development; histidine biosynthetic process; methionine biosynthetic process; methionine metabolic process; neural tube closure; one-carbon metabolic process; oxidation-reduction process; purine nucleotide biosynthetic process; serine family amino acid biosynthetic process; serine family amino acid metabolic process; somite development; tetrahydrofolate interconversion
Disease: Combined Immunodeficiency And Megaloblastic Anemia With Or Without Hyperhomocysteinemia; Neural Tube Defects, Folate-sensitive
Reference #:  P11586 (UniProtKB)
Alt. Names/Synonyms: 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase; C-1-tetrahydrofolate synthase, cytoplasmic; C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed; C1-THF synthase; C1TC; CIMAH; cytoplasmic C-1-tetrahydrofolate synthase; epididymis secretory sperm binding protein; Formyltetrahydrofolate synthetase; Methenyltetrahydrofolate cyclohydrolase; Methylenetetrahydrofolate dehydrogenase; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase; methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1; MTHFC; MTHFD; MTHFD1
Gene Symbols: MTHFD1
Molecular weight: 101,559 Da
Basal Isoelectric point: 6.89  Predict pI for various phosphorylation states
Select Structure to View Below

MTHFD1

Protein Structure Not Found.


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