SHMT2 Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs. Associates with mitochondrial DNA. In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex. Belongs to the SHMT family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - glycine, serine and threonine; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC; Energy Metabolism - methane; Methyltransferase; Mitochondrial; Other Amino Acids Metabolism - cyanoamino acid
Chromosomal Location of Human Ortholog: 10|10 D3
Cellular Component:  BRISC complex; cytoplasm; membrane; microtubule cytoskeleton; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrial matrix; mitochondrial nucleoid; mitochondrion; nucleus
Molecular Function:  amino acid binding; catalytic activity; chromatin binding; cobalt ion binding; glycine hydroxymethyltransferase activity; identical protein binding; L-allo-threonine aldolase activity; pyridoxal phosphate binding; serine binding; transferase activity; zinc ion binding
Biological Process:  cellular response to tetrahydrofolate; folic acid metabolic process; glycine biosynthetic process; glycine biosynthetic process from serine; glycine metabolic process; L-serine biosynthetic process; L-serine catabolic process; L-serine metabolic process; one-carbon metabolic process; positive regulation of cell proliferation; protein homotetramerization; protein K63-linked deubiquitination; protein tetramerization; regulation of aerobic respiration; regulation of mitochondrial translation; regulation of oxidative phosphorylation; response to type I interferon; tetrahydrofolate interconversion; tetrahydrofolate metabolic process
Reference #:  Q9CZN7 (UniProtKB)
Alt. Names/Synonyms: 2700043D08Rik; AA408223; AA986903; Glycine hydroxymethyltransferase; GLYM; Serine hydroxymethyltransferase; serine hydroxymethyltransferase 2 (mitochondrial); Serine hydroxymethyltransferase, mitochondrial; Serine methylase; SHMT; Shmt2
Gene Symbols: Shmt2
Molecular weight: 55,759 Da
Basal Isoelectric point: 8.73  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene