POM121 Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). Belongs to the POM121 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Nucleoporin
Chromosomal Location of mouse Ortholog: 5|5 G2
Cellular Component:  endoplasmic reticulum; membrane; nuclear envelope; nuclear membrane; nuclear pore; nucleoplasm; nucleus
Molecular Function:  nuclear localization sequence binding; structural constituent of nuclear pore
Biological Process:  mRNA transport; nuclear pore organization; nucleocytoplasmic transport; protein import into nucleus; protein transport; RNA export from nucleus
Reference #:  Q8K3Z9 (UniProtKB)
Alt. Names/Synonyms: 2610027A18Rik; C80273; mKIAA0618; Nuclear envelope pore membrane protein POM 121; nuclear pore membrane protein 121; Nucleoporin Nup121; Nup121; PO121; Pom121; Pore membrane protein of 121 kDa
Gene Symbols: Pom121
Molecular weight: 121,022 Da
Basal Isoelectric point: 10.21  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene