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POM121C
Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). Belongs to the POM121 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral |
| Chromosomal Location of human Ortholog: 7q11.23 |
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Cellular Component:
endoplasmic reticulum membrane; nuclear envelope; nuclear membrane; nuclear pore; nucleoplasm
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Molecular Function:
nuclear localization sequence binding; protein binding; structural constituent of nuclear pore
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Biological Process:
mRNA transport; protein import into nucleus; RNA export from nucleus
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Reference #:
A8CG34
(UniProtKB)
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Alt. Names/Synonyms: DKFZp586P2220; DKFZp779K1713; FLJ43877; FLJ45082; MGC163459; MGC163461; Nuclear envelope pore membrane protein POM 121C; Nuclear pore membrane protein 121-2; P121C; POM121 membrane glycoprotein C; POM121 membrane glycoprotein-like; POM121 transmembrane nucleoporin C; POM121-2; POM121C; Pore membrane protein of 121 kDa C
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Gene Symbols: POM121C
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Molecular weight:
125,092 Da
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Basal Isoelectric point:
10.38
Predict pI for various phosphorylation states
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