ME2 Belongs to the malic enzymes family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - pyruvate; EC 1.1.1.38; Mitochondrial; Oxidoreductase
Chromosomal Location of human Ortholog: 18q21.2
Cellular Component:  intracellular membrane-bounded organelle; mitochondrial matrix; mitochondrion
Molecular Function:  electron transfer activity; malate dehydrogenase (decarboxylating) (NAD+) activity; malate dehydrogenase (decarboxylating) (NADP+) activity; malic enzyme activity; metal ion binding; NAD binding; oxaloacetate decarboxylase activity
Biological Process:  electron transport chain; malate metabolic process; pyruvate metabolic process; regulation of NADP metabolic process
Disease: Epilepsy, Idiopathic Generalized; Opioid Dependence, Susceptibility To, 1
Reference #:  P23368 (UniProtKB)
Alt. Names/Synonyms: malate dehydrogenase (oxaloacetate-decarboxylating); Malic enzyme 2; malic enzyme 2, NAD(+)-dependent, mitochondrial; MAOM; ME2; NAD-dependent malic enzyme, mitochondrial; NAD-ME; ODS1; pyruvic-malic carboxylase
Gene Symbols: ME2
Molecular weight: 65,444 Da
Basal Isoelectric point: 7.52  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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ME2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB