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ZNF313
E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle's G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis. Expressed in numerous tissues, including skin, CD4 lymphocytes and dendritic cells. Highest levels in testis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Transcription factor; Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of human Ortholog: 20q13.13 |
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Cellular Component:
cytosol; nucleus; plasma membrane
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Molecular Function:
metal ion binding; protein binding; ubiquitin protein ligase activity
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Biological Process:
cell differentiation; protein polyubiquitination; spermatogenesis; ubiquitin-dependent protein catabolic process
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Reference #:
Q9Y508
(UniProtKB)
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Alt. Names/Synonyms: E3 ubiquitin-protein ligase RNF114; PSORS12; RING finger protein 114; RING-type E3 ubiquitin transferase RNF114; RN114; RNF114; Zinc finger protein 228; Zinc finger protein 313; ZNF228; ZNF313
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Gene Symbols: RNF114
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Molecular weight:
25,694 Da
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Basal Isoelectric point:
6.99
Predict pI for various phosphorylation states
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