ZNF313 E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle's G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis. Expressed in numerous tissues, including skin, CD4 lymphocytes and dendritic cells. Highest levels in testis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 20q13.13
Cellular Component:  cytosol; nucleus; plasma membrane
Molecular Function:  metal ion binding; transferase activity
Biological Process:  cell differentiation; multicellular organism development; protein polyubiquitination; spermatogenesis
Reference #:  Q9Y508 (UniProtKB)
Alt. Names/Synonyms: E3 ubiquitin-protein ligase RNF114; PSORS12; RING finger protein 114; RING-type E3 ubiquitin transferase RNF114; RN114; RNF114; Zinc finger protein 228; Zinc finger protein 313; ZNF228; ZNF313
Gene Symbols: RNF114
Molecular weight: 25,694 Da
Basal Isoelectric point: 6.99  Predict pI for various phosphorylation states
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ZNF313

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene