SKIV2L2 Component of exosome targeting complexes. Subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA. May be involved in pre-mRNA splicing. Belongs to the helicase family. SKI2 subfamily. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; EC 3.6.4.13; Helicase; Nucleolus; Spliceosome
Chromosomal Location of mouse Ortholog: 13|13 D2.2
Cellular Component:  catalytic step 2 spliceosome; exosome (RNase complex); nuclear exosome (RNase complex); nucleoplasm; nucleus; spliceosomal complex; TRAMP complex
Molecular Function:  ATP binding; helicase activity; hydrolase activity; nucleic acid binding; nucleotide binding; RNA binding; RNA helicase activity
Biological Process:  DNA damage response; maturation of 5.8S rRNA; mRNA processing; RNA catabolic process; RNA splicing; rRNA processing
Reference #:  Q9CZU3 (UniProtKB)
Alt. Names/Synonyms: 2610528A15Rik; ATP-dependent helicase SKIV2L2; Exosome RNA helicase MTR4; mKIAA0052; Mtr4 exosome RNA helicase; MTREX; SK2L2; Ski; Skiv2l2; Superkiller viralicidic activity 2-like 2; superkiller viralicidic activity 2-like 2 (S. cerevisiae); TRAMP-like complex helicase
Gene Symbols: Mtrex
Molecular weight: 117,636 Da
Basal Isoelectric point: 6.01  Predict pI for various phosphorylation states
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SKIV2L2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein