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SKIV2L2
Component of exosome targeting complexes. Subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA. May be involved in pre-mRNA splicing. Belongs to the helicase family. SKI2 subfamily. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; EC 3.6.4.13; Helicase; Nucleolus; Spliceosome |
| Chromosomal Location of human Ortholog: 5q11.2 |
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Cellular Component:
catalytic step 2 spliceosome; nuclear speck; nucleolus; nucleoplasm; nucleus; TRAMP complex
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Molecular Function:
ATP binding; ATP hydrolysis activity; protein binding; RNA helicase activity
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Biological Process:
DNA damage response; maturation of 5.8S rRNA; mRNA splicing, via spliceosome; RNA catabolic process; rRNA processing; snRNA catabolic process
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Reference #:
P42285
(UniProtKB)
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Alt. Names/Synonyms: ATP-dependent helicase SKIV2L2; ATP-dependent RNA helicase DOB1; ATP-dependent RNA helicase SKIV2L2; Dob1; Exosome RNA helicase MTR4; fSAP118; functional spliceosome-associated protein 118; KIAA0052; MGC142069; Mtr4; Mtr4 exosome RNA helicase; MTREX; SK2L2; Ski2 like RNA helicase 2; SKIV2L2; Superkiller viralicidic activity 2-like 2; superkiller viralicidic activity 2-like 2 (S. cerevisiae); TRAMP-like complex helicase
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Gene Symbols: MTREX
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Molecular weight:
117,805 Da
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Basal Isoelectric point:
6.12
Predict pI for various phosphorylation states
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