PHF22 Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. Belongs to the Integrator subunit 12 family. Note: This description may include information from UniProtKB.
Protein type: RNA-binding
Chromosomal Location of Human Ortholog: 3|3 G3
Cellular Component:  integrator complex; nucleus
Molecular Function:  metal ion binding
Biological Process:  snRNA 3'-end processing; snRNA processing
Reference #:  Q9D168 (UniProtKB)
Alt. Names/Synonyms: 1110020M19Rik; 2810027J24Rik; 4930529N21Rik; A230056J18Rik; AI666778; Int12; Integrator complex subunit 12; Ints12; OTTMUSP00000019052; PHD finger protein 22; Phf22
Gene Symbols: Ints12
Molecular weight: 48,568 Da
Basal Isoelectric point: 9.72  Predict pI for various phosphorylation states
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PHF22

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene