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PHF22
Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. Belongs to the Integrator subunit 12 family. Note: This description may include information from UniProtKB.
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| Protein type: RNA-binding |
| Chromosomal Location of human Ortholog: 4q24 |
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Cellular Component:
integrator complex; nucleoplasm; nucleus
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Molecular Function:
metal ion binding; protein binding
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Biological Process:
regulation of transcription elongation by RNA polymerase II; snRNA 3'-end processing; snRNA processing
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Reference #:
Q96CB8
(UniProtKB)
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Alt. Names/Synonyms: hypothetical nuclear factor SBBI22; Int12; Integrator complex subunit 12; INTS12; PHD finger protein 22; PHF22; SBBI22
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Gene Symbols: INTS12
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Molecular weight:
48,808 Da
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Basal Isoelectric point:
9.72
Predict pI for various phosphorylation states
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