MED6 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 6 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 12|12 D1
Cellular Component:  core mediator complex; mediator complex; nucleoplasm; nucleus; ubiquitin ligase complex
Molecular Function:  DNA binding; protein binding; transcription coactivator activity; transcription coregulator activity; transcription factor binding
Biological Process:  positive regulation of transcription by RNA polymerase II; protein ubiquitination; regulation of transcription by RNA polymerase II; RNA polymerase II preinitiation complex assembly; stem cell population maintenance
Reference #:  Q921D4 (UniProtKB)
Alt. Names/Synonyms: 1500012F11Rik; AU019660; AV213303; Med6; Mediator complex subunit 6; Mediator of RNA polymerase II transcription subunit 6; mediator of RNA polymerase II transcription, subunit 6 homolog (yeast)
Gene Symbols: Med6
Molecular weight: 28,434 Da
Basal Isoelectric point: 8.71  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein