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MED6
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 6 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Transcription factor |
| Chromosomal Location of human Ortholog: 14q24.2 |
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Cellular Component:
core mediator complex; mediator complex; nucleoplasm; nucleus; ubiquitin ligase complex
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Molecular Function:
DNA binding; protein binding; transcription coactivator activity; transcription coactivator binding; ubiquitin protein ligase activity
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Biological Process:
positive regulation of transcription by RNA polymerase II; positive regulation of transcription elongation by RNA polymerase II; positive regulation of transcription initiation by RNA polymerase II; protein ubiquitination; regulation of transcription by RNA polymerase II; RNA polymerase II preinitiation complex assembly; somatic stem cell population maintenance
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Reference #:
O75586
(UniProtKB)
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Alt. Names/Synonyms: Activator-recruited cofactor 33 kDa component; ARC33; CTD-2540L5.5; hMed6; MED6; Mediator complex subunit 6; Mediator of RNA polymerase II transcription subunit 6; mediator of RNA polymerase II transcription, subunit 6 homolog; NY-REN-28; Renal carcinoma antigen NY-REN-28
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Gene Symbols: MED6
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Molecular weight:
28,425 Da
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Basal Isoelectric point:
8.71
Predict pI for various phosphorylation states
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