EIF4E Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. Belongs to the eukaryotic initiation factor 4E family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation initiation
Chromosomal Location of Human Ortholog: 4q23
Cellular Component:  chromatoid body; cytoplasm; cytoplasmic ribonucleoprotein granule; cytoplasmic stress granule; cytosol; eukaryotic translation initiation factor 4F complex; glutamatergic synapse; mRNA cap binding complex; P-body; perinuclear region of cytoplasm; postsynaptic cytosol; RISC complex
Molecular Function:  enzyme binding; eukaryotic initiation factor 4G binding; protein binding; repressing transcription factor binding; RNA 7-methylguanosine cap binding; RNA cap binding; translation initiation factor activity
Biological Process:  behavioral fear response; cellular response to dexamethasone stimulus; G1/S transition of mitotic cell cycle; lung development; mRNA export from nucleus; negative regulation of neuron differentiation; negative regulation of translation; positive regulation of mitotic cell cycle; regulation of translation; regulation of translation at postsynapse, modulating synaptic transmission; RNA export from nucleus; stem cell population maintenance; translational initiation; viral process
Disease: Autism, Susceptibility To, 19
Reference #:  P06730 (UniProtKB)
Alt. Names/Synonyms: CBP; eIF-4E; eIF-4F 25 kDa subunit; EIF4E; EIF4E1; EIF4EL1; EIF4F; Eukaryotic translation initiation factor 4E; eukaryotic translation initiation factor 4E-like 1; IF4E; MGC111573; mRNA cap-binding protein
Gene Symbols: EIF4E
Molecular weight: 25,097 Da
Basal Isoelectric point: 5.79  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  Insulin Receptor Signaling  |  Translation: eIF4E and p70S6K  |  Translational Control
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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EIF4E

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene