EIF4E a protein of the eukaryotic initiation factor 4E family. Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the EIF4F complex. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation initiation
Chromosomal Location of Human Ortholog: 4q23
Cellular Component:  chromatoid body; cytoplasm; cytoplasmic ribonucleoprotein granule; cytoplasmic stress granule; cytosol; eukaryotic translation initiation factor 4F complex; glutamatergic synapse; mRNA cap binding complex; P-body; perinuclear region of cytoplasm; postsynaptic cytosol; RISC complex
Molecular Function:  enzyme binding; eukaryotic initiation factor 4G binding; protein binding; repressing transcription factor binding; RNA 7-methylguanosine cap binding; RNA cap binding; translation initiation factor activity
Biological Process:  behavioral fear response; cellular response to dexamethasone stimulus; G1/S transition of mitotic cell cycle; lung development; mRNA export from nucleus; negative regulation of neuron differentiation; negative regulation of translation; positive regulation of mitotic cell cycle; regulation of translation; regulation of translation at postsynapse, modulating synaptic transmission; RNA export from nucleus; stem cell population maintenance; translational initiation; viral process
Disease: Autism, Susceptibility To, 19
Reference #:  P06730 (UniProtKB)
Alt. Names/Synonyms: CBP; eIF-4E; eIF-4F 25 kDa subunit; EIF4E; EIF4E1; EIF4EL1; EIF4F; Eukaryotic translation initiation factor 4E; eukaryotic translation initiation factor 4E-like 1; IF4E; MGC111573; mRNA cap-binding protein
Gene Symbols: EIF4E
Molecular weight: 25,097 Da
Basal Isoelectric point: 5.79  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  Insulin Receptor Signaling  |  Translation: eIF4E and p70S6K  |  Translational Control
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene