PMPCA Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which is required for maturation of the majority of mitochondrial precursor proteins. Most MPP cleavage sites follow an arginine at position -2. Belongs to the peptidase M16 family. Ubiquitously expressed with highest expression in fetal tissues and adult brain, cerebellum and cerebellar vermis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.24.64; Mitochondrial; Protease
Chromosomal Location of mouse Ortholog: 2|2 A3
Cellular Component:  membrane; mitochondrial inner membrane; mitochondrial processing peptidase complex; mitochondrion
Molecular Function:  catalytic activity; endopeptidase activity; metal ion binding; metalloendopeptidase activity
Biological Process:  protein processing involved in protein targeting to mitochondrion; proteolysis
Reference #:  Q9DC61 (UniProtKB)
Alt. Names/Synonyms: 1200002L24Rik; 4933435E07Rik; Alp; Alpha-MPP; Inactive zinc metalloprotease alpha; Inpp5e; mitochondrial matrix processing protease, alpha subunit; Mitochondrial-processing peptidase subunit alpha; MPPA; OTTMUSP00000013720; P-55; peptidase (mitochondrial processing) alpha; Pmpca
Gene Symbols: Pmpca
Molecular weight: 58,279 Da
Basal Isoelectric point: 6.36  Predict pI for various phosphorylation states
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PMPCA

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein