RPS23 Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays an important role in translational accuracy. Belongs to the universal ribosomal protein uS12 family. Note: This description may include information from UniProtKB.

Protein type: Ribosomal; Translation

Chromosomal Location of Human Ortholog: 5q14.2

Cellular Component: cytosol; cytosolic small ribosomal subunit; endoplasmic reticulum; nucleoplasm; polysomal ribosome; ribosome; rough endoplasmic reticulum; synapse

Molecular Function: protein binding; structural constituent of ribosome

Biological Process: cytoplasmic translation; maintenance of translational fidelity; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; SRP-dependent cotranslational protein targeting to membrane; stress granule assembly; translation; translational initiation; viral transcription

Disease: Macinnes Syndrome

Reference #: P62266 (UniProtKB)

Alt. Names/Synonyms: 40S ribosomal protein S23; BTDD; FLJ35016; homolog of yeast ribosomal protein S28; MABAS; MCINS; PAMAS; ribosomal protein S23; RPS23; RS23; S23; Small ribosomal subunit protein uS12; uS12

Gene Symbols: RPS23

Molecular weight: 15,808 Da

Basal Isoelectric point: 10.5 Predict pI for various phosphorylation states

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RPS23

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