PPIL2 Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation. May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily. Highest expression in thymus, pancreas and testis. Also detected in heart, placenta, lung, liver, skeletal muscle, kidney, spleen, prostate, ovary, small intestine and colon. Poorly detected in brain and leukocytes. Strong protein expression in lymph node (cortical, paracortical and medullar regions), thyroid (follicular epithelial cells), testis (developing spermatozoa), stomach (cells lining the gastric pit), pancreas, kidney (proximal and distal-tubule cells and collecting duct cells but not in glomeruli), endometrium and colon (goblet cells). Moderate protein expression in spleen, prostate (epithelium and squamous cell carcinomas), placenta and adrenal gland. Weak protein expression in liver, heart, breast, ovary, and lung. No protein expression in brain and bladder. High protein expression in most lymphomas and melanomas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cyclophilin; EC; Isomerase; Ligase; Spliceosome; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 22q11.21-q11.22
Cellular Component:  cytoplasm; Golgi lumen; nucleoplasm; nucleus; plasma membrane
Molecular Function:  protein binding; ubiquitin protein ligase activity; ubiquitin-ubiquitin ligase activity
Biological Process:  leukocyte migration; protein folding; protein localization to plasma membrane; protein polyubiquitination
Reference #:  Q13356 (UniProtKB)
Alt. Names/Synonyms: CYC4; cyclophilin, 60kDa; Cyclophilin-60; Cyclophilin-like protein Cyp-60; Cyp-60; CYP60; FLJ39930; hCyP-60; MGC33174; MGC787; Peptidyl-prolyl cis-trans isomerase-like 2; peptidylprolyl cis-trans isomerase; peptidylprolyl isomerase (cyclophilin)-like 2; peptidylprolyl isomerase like 2; PPIase; PPIL2; Probable inactive peptidyl-prolyl cis-trans isomerase-like 2; RING-type E3 ubiquitin transferase isomerase-like 2; RING-type E3 ubiquitin-protein ligase PPIL2; Rotamase PPIL2; U-box domain containing 7; UBOX7
Gene Symbols: PPIL2
Molecular weight: 58,823 Da
Basal Isoelectric point: 8.92  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein