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PES1
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. Belongs to the pescadillo family. Significant levels are detected in a variety of cancer cell lines, including glioblastoma, breast carcinoma, colon carcinoma and cervical carcinoma cells. Levels are abnormally elevated in malignant tumors of astrocytic origin. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Nucleolus; RNA-binding; Translation |
| Chromosomal Location of mouse Ortholog: 11|11 A1 |
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Cellular Component:
chromosome; condensed chromosome; cytosol; nucleolus; nucleoplasm; nucleus; PeBoW complex; preribosome, large subunit precursor
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Molecular Function:
protein binding; RNA binding
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Biological Process:
fibroblast proliferation; maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); nucleolus organization; protein localization to organelle; regulation of cell cycle; ribosome biogenesis; rRNA processing
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Reference #:
Q9EQ61
(UniProtKB)
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Alt. Names/Synonyms: Pes; Pes1; PESC; Pescadillo homolog; pescadillo homolog 1, containing BRCT domain; pescadillo homolog 1, containing BRCT domain (zebrafish); pescadillo ribosomal biogenesis factor 1
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Gene Symbols: Pes1
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Molecular weight:
67,796 Da
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Basal Isoelectric point:
6.41
Predict pI for various phosphorylation states
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