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RALB
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Required for suppression of apoptosis. In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission. Belongs to the small GTPase superfamily. Ras family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: G protein; G protein, monomeric; G protein, monomeric, Ras |
| Chromosomal Location of Human Ortholog: 1|1 E2.3 |
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Cellular Component:
membrane; midbody; plasma membrane
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Molecular Function:
ATPase binding; GDP binding; GTP binding; GTPase activity; nucleotide binding; ubiquitin protein ligase binding
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Biological Process:
apoptotic process; cell cycle; cell division; cellular response to exogenous dsRNA; cellular response to starvation; negative regulation of protein binding; positive regulation of autophagosome assembly; positive regulation of protein binding; positive regulation of protein phosphorylation; positive regulation of protein serine/threonine kinase activity; Ras protein signal transduction; regulation of exocyst assembly; regulation of exocyst localization; signal transduction
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Reference #:
Q9JIW9
(UniProtKB)
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Alt. Names/Synonyms: 5730472O18Rik; OTTMUSP00000024377; Ralb; Ras-related protein Ral-B; v-ral simian leukemia viral oncogene B; v-ral simian leukemia viral oncogene homolog B (ras related)
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Gene Symbols: Ralb
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Molecular weight:
23,349 Da
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Basal Isoelectric point:
6.24
Predict pI for various phosphorylation states
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