UBLE1A The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. Expression level increases during S phase and drops in G2 phase (at protein level). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; SUMO conjugating system; SUMO ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 7 A2|7 8.88 cM
Cellular Component:  cytoplasm; nucleus; SUMO activating enzyme complex
Molecular Function:  ATP-dependent protein binding; ligase activity; protein C-terminus binding; protein heterodimerization activity; small protein activating enzyme binding; SUMO activating enzyme activity; ubiquitin-like modifier activating enzyme activity
Biological Process:  cellular protein modification process; protein modification by small protein conjugation; protein sumoylation
Reference #:  Q9R1T2 (UniProtKB)
Alt. Names/Synonyms: 2400010M20Rik; 2610044L12Rik; AL033372; Aos1; AW743391; D7Ertd177; D7Ertd177e; HSPC1; HSPC140; Sae1; Sua1; SUMO-1 activating enzyme subunit 1; SUMO-activating enzyme subunit 1; SUMO-activating enzyme subunit 1, N-terminally processed; SUMO1 activating enzyme subunit 1; ubiquitin-like (sentrin) activating enzyme E1A; ubiquitin-like 1 (sentrin) activating enzyme E1A; ubiquitin-like 1 (sentrin) activating enzyme subunit 1; Ubiquitin-like 1-activating enzyme E1A; Ubl1a1; Uble; Uble1a
Gene Symbols: Sae1
Molecular weight: 38,620 Da
Basal Isoelectric point: 5.24  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene