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UBLE1A
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. Expression level increases during S phase and drops in G2 phase (at protein level). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 6.3.2.19; SUMO conjugating system; SUMO ligase; Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of mouse Ortholog: 7 A2|7 8.88 cM |
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Cellular Component:
cytoplasm; nucleoplasm; nucleus; SUMO activating enzyme complex
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Molecular Function:
ATP-dependent protein binding; ligase activity; protein heterodimerization activity; small protein activating enzyme binding; SUMO activating enzyme activity; ubiquitin-like modifier activating enzyme activity
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Biological Process:
positive regulation of protein sumoylation; protein modification process; protein sumoylation
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Reference #:
Q9R1T2
(UniProtKB)
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Alt. Names/Synonyms: 2400010M20Rik; 2610044L12Rik; AL033372; Aos1; AW743391; D7Ertd177; D7Ertd177e; HSPC1; HSPC140; Sae1; Sua1; SUMO-1 activating enzyme subunit 1; SUMO-activating enzyme subunit 1; SUMO-activating enzyme subunit 1, N-terminally processed; SUMO1 activating enzyme subunit 1; ubiquitin-like (sentrin) activating enzyme E1A; ubiquitin-like 1 (sentrin) activating enzyme E1A; ubiquitin-like 1 (sentrin) activating enzyme subunit 1; Ubiquitin-like 1-activating enzyme E1A; Ubl1a1; Uble; Uble1a
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Gene Symbols: Sae1
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Molecular weight:
38,620 Da
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Basal Isoelectric point:
5.24
Predict pI for various phosphorylation states
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