UBLE1A The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. Expression level increases during S phase and drops in G2 phase (at protein level). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; SUMO conjugating system; SUMO ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of human Ortholog: 19q13.32
Cellular Component:  cytoplasm; nucleoplasm; SUMO activating enzyme complex
Molecular Function:  ATP-dependent protein binding; enzyme activator activity; protein binding; protein heterodimerization activity; small protein activating enzyme binding; SUMO activating enzyme activity; ubiquitin activating enzyme activity
Biological Process:  positive regulation of protein sumoylation; protein sumoylation; protein ubiquitination
Reference #:  Q9UBE0 (UniProtKB)
Alt. Names/Synonyms: activator of SUMO1; AOS1; FLJ3091; HSPC140; SAE1; sentrin/SUMO-activating protein AOS1; SUA1; SUMO-1 activating enzyme E1 N subunit; SUMO-1 activating enzyme subunit 1; SUMO-activating enzyme subunit 1; SUMO-activating enzyme subunit 1, N-terminally processed; SUMO1 activating enzyme subunit 1; Ubiquitin-like 1-activating enzyme E1A; ubiquitin-like protein SUMO-1 activating enzyme; UBLE1A
Gene Symbols: SAE1
Molecular weight: 38,450 Da
Basal Isoelectric point: 5.17  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein