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EEF2
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. Note: This description may include information from UniProtKB.
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| Protein type: Translation; Translation elongation |
| Chromosomal Location of human Ortholog: 19p13.3 |
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Cellular Component:
aggresome; cytoplasm; cytosol; extracellular region; ficolin-1-rich granule lumen; membrane raft; plasma membrane; polysomal ribosome; ribonucleoprotein complex; secretory granule lumen; synapse
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Molecular Function:
5S rRNA binding; actin filament binding; GTP binding; p53 binding; protein binding; protein kinase binding
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Biological Process:
aging; cellular response to brain-derived neurotrophic factor stimulus; glial cell proliferation; hematopoietic progenitor cell differentiation; neutrophil degranulation; positive regulation of cytoplasmic translation; positive regulation of translation; response to endoplasmic reticulum stress; response to estradiol; response to ethanol; response to folic acid; response to hydrogen peroxide; response to ischemia; skeletal muscle cell differentiation; skeletal muscle contraction; translational elongation
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Disease: Spinocerebellar Ataxia 26
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Reference #:
P13639
(UniProtKB)
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Alt. Names/Synonyms: EEF-2; EEF2; EF-2; EF2; Elongation factor 2; epididymis secretory sperm binding protein; eukaryotic translation elongation factor 2; polypeptidyl-tRNA translocase; SCA26
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Gene Symbols: EEF2
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Molecular weight:
95,338 Da
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Basal Isoelectric point:
6.41
Predict pI for various phosphorylation states
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CST Pathways:
AMPK Signaling
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Translational Control
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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