PNUTS Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers. Note: This description may include information from UniProtKB.
Protein type: Protein phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 17 B1|17 18.77 cM
Cellular Component:  chromatin; nuclear body; nuclear chromatin; nucleoplasm; nucleus; PTW/PP1 phosphatase complex
Molecular Function:  DNA binding; metal ion binding; protein binding; protein phosphatase 1 binding; protein phosphatase inhibitor activity; RNA binding
Biological Process:  negative regulation of cardiac muscle cell apoptotic process; negative regulation of mitotic DNA damage checkpoint; positive regulation of telomere maintenance
Reference #:  Q80W00 (UniProtKB)
Alt. Names/Synonyms: 2610025H06Rik; Cat53; D17Ertd808e; Fb19; HLA-C adjacent transcript 53; MHC class I region proline-rich protein CAT53; Pnuts; PP1RA; Ppp1r10; protein phosphatase 1, regulatory subunit 10; protein phosphatase I; Serine/threonine-protein phosphatase 1 regulatory subunit 10
Gene Symbols: Ppp1r10
Molecular weight: 94,372 Da
Basal Isoelectric point: 9.21  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PNUTS

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene