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PNUTS
Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Note: This description may include information from UniProtKB.
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| Protein type: Protein phosphatase, regulatory subunit |
| Chromosomal Location of mouse Ortholog: 17 B1|17 18.77 cM |
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Cellular Component:
chromatin; chromosome, telomeric region; nuclear body; nucleoplasm; nucleus; PTW/PP1 phosphatase complex
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Molecular Function:
DNA binding; metal ion binding; protein binding; protein phosphatase 1 binding; protein phosphatase inhibitor activity; RNA binding
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Biological Process:
negative regulation of cardiac muscle cell apoptotic process; negative regulation of mitotic DNA damage checkpoint; positive regulation of telomere maintenance
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Reference #:
Q80W00
(UniProtKB)
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Alt. Names/Synonyms: 2610025H06Rik; Cat53; D17Ertd808; D17Ertd808e; Fb19; HLA-C adjacent transcript 53; MHC class I region proline-rich protein CAT53; Pnuts; PP1RA; Ppp1r10; protein phosphatase 1, regulatory subunit 10; protein phosphatase I; Serine/threonine-protein phosphatase 1 regulatory subunit 10
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Gene Symbols: Ppp1r10
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Molecular weight:
94,372 Da
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Basal Isoelectric point:
9.21
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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