PNUTS Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Note: This description may include information from UniProtKB.
Protein type: Protein phosphatase, regulatory subunit
Chromosomal Location of human Ortholog: 6p21.33
Cellular Component:  chromatin; chromosome, telomeric region; nuclear body; nucleoplasm; nucleus; PTW/PP1 phosphatase complex
Molecular Function:  DNA binding; metal ion binding; protein binding; protein phosphatase 1 binding; protein phosphatase inhibitor activity
Biological Process:  negative regulation of cardiac muscle cell apoptotic process; negative regulation of mitotic DNA damage checkpoint; positive regulation of telomere maintenance; protein import into nucleus
Reference #:  Q96QC0 (UniProtKB)
Alt. Names/Synonyms: CAT53; FB19; HLA-C associated transcript 53; MHC class I region proline-rich protein CAT53; p99; Phosphatase 1 nuclear targeting subunit; phosphatase nuclear targeting subunit; PNUTS; PP1-binding protein of 114 kDa; PP1R10; PP1RA; PPP1R10; Protein FB19; protein phosphatase 1 regulatory subunit 10; protein phosphatase 1, regulatory (inhibitor) subunit 10; protein phosphatase 1, regulatory subunit 10; R111; Serine/threonine-protein phosphatase 1 regulatory subunit 10; testis tissue sperm-binding protein Li 67n
Gene Symbols: PPP1R10
Molecular weight: 99,058 Da
Basal Isoelectric point: 9.22  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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PNUTS

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein