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VAPA
Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking. Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Endoplasmic reticulum; Membrane protein, integral |
| Chromosomal Location of Human Ortholog: 17|17 E1.1 |
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Cellular Component:
cell junction; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi membrane; integral component of membrane; membrane; microtubule cytoskeleton; nuclear membrane; nucleus; plasma membrane; vesicle
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Molecular Function:
FFAT motif binding; identical protein binding; microtubule binding; protein binding; protein domain specific binding; protein heterodimerization activity
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Biological Process:
cell death; COPII-coated vesicle budding; ER to Golgi vesicle-mediated transport; negative regulation by host of viral genome replication; neuron projection development; positive regulation by host of viral genome replication; positive regulation by host of viral release from host cell; protein localization to endoplasmic reticulum
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Reference #:
Q9WV55
(UniProtKB)
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Alt. Names/Synonyms: 33 kDa VAMP-associated protein; 33kDa; synaptobrevin-associated protein of 33kDa; VAMP-A; VAMP-associated protein A; VAP-33; VAP-A; Vap33; Vapa; vesicle-associated membrane protein, associated protein A; Vesicle-associated membrane protein-associated protein A
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Gene Symbols: Vapa
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Molecular weight:
27,855 Da
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Basal Isoelectric point:
8.58
Predict pI for various phosphorylation states
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