VAPA Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking. Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Endoplasmic reticulum; Membrane protein, integral
Chromosomal Location of Human Ortholog: 17|17 E1.1
Cellular Component:  cell junction; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi membrane; integral component of membrane; membrane; microtubule cytoskeleton; nuclear membrane; nucleus; plasma membrane; vesicle
Molecular Function:  FFAT motif binding; identical protein binding; microtubule binding; protein binding; protein domain specific binding; protein heterodimerization activity
Biological Process:  cell death; COPII-coated vesicle budding; ER to Golgi vesicle-mediated transport; negative regulation by host of viral genome replication; neuron projection development; positive regulation by host of viral genome replication; positive regulation by host of viral release from host cell; protein localization to endoplasmic reticulum
Reference #:  Q9WV55 (UniProtKB)
Alt. Names/Synonyms: 33 kDa VAMP-associated protein; 33kDa; synaptobrevin-associated protein of 33kDa; VAMP-A; VAMP-associated protein A; VAP-33; VAP-A; Vap33; Vapa; vesicle-associated membrane protein, associated protein A; Vesicle-associated membrane protein-associated protein A
Gene Symbols: Vapa
Molecular weight: 27,855 Da
Basal Isoelectric point: 8.58  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene