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VAPA
Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking. Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Endoplasmic reticulum; Membrane protein, integral |
| Chromosomal Location of human Ortholog: 18p11.22 |
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Cellular Component:
azurophil granule membrane; bicellular tight junction; cytosol; endoplasmic reticulum; endoplasmic reticulum exit site; endoplasmic reticulum membrane; Golgi membrane; microtubule cytoskeleton; nuclear membrane; perinuclear region of cytoplasm; plasma membrane; vesicle
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Molecular Function:
FFAT motif binding; microtubule binding; protein binding; protein domain specific binding; protein heterodimerization activity
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Biological Process:
ceramide transport; COPII-coated vesicle budding; endoplasmic reticulum organization; endoplasmic reticulum to Golgi vesicle-mediated transport; membrane fusion; negative regulation by host of viral genome replication; neuron projection development; phospholipid transport; positive regulation by host of viral genome replication; protein folding in endoplasmic reticulum; protein localization to endoplasmic reticulum; sphingomyelin biosynthetic process; sterol transport; viral release from host cell
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Reference #:
Q9P0L0
(UniProtKB)
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Alt. Names/Synonyms: 33 kDa VAMP-associated protein; epididymis secretory sperm binding protein; hVAP-33; MGC3745; VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa; VAMP associated protein A; VAMP-A; VAMP-associated protein A; VAP-33; VAP-A; VAP33; VAPA; Vesicle-associated membrane protein-associated protein A
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Gene Symbols: VAPA
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Molecular weight:
27,893 Da
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Basal Isoelectric point:
8.8
Predict pI for various phosphorylation states
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