GNPDA1 Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo. Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC; Hydrolase; Isomerase
Chromosomal Location of mouse Ortholog: 18|18 B3
Cellular Component:  cytoplasm
Molecular Function:  glucosamine-6-phosphate deaminase activity; hydrolase activity; identical protein binding
Biological Process:  acrosome reaction; carbohydrate metabolic process; fructose 6-phosphate metabolic process; fructose biosynthetic process; generation of precursor metabolites and energy; glucosamine catabolic process; glucosamine metabolic process; N-acetylglucosamine catabolic process; N-acetylglucosamine metabolic process; N-acetylneuraminate catabolic process; UDP-N-acetylglucosamine biosynthetic process
Reference #:  O88958 (UniProtKB)
Alt. Names/Synonyms: GlcN6P deaminase 1; Glucosamine-6-phosphate deaminase 1; Glucosamine-6-phosphate isomerase 1; glucose-6-phosphate isomerase; Gnp1; GNPDA; GNPDA 1; Gnpda1; Gnpi; GNPI1; KIAA0060; Oscillin
Gene Symbols: Gnpda1
Molecular weight: 32,549 Da
Basal Isoelectric point: 6.13  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene