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GNPDA1
Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo. Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC 3.5.99.6; Hydrolase; Isomerase |
| Chromosomal Location of mouse Ortholog: 18|18 B3 |
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Cellular Component:
cytoplasm
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Molecular Function:
glucosamine-6-phosphate deaminase activity; hydrolase activity; identical protein binding; isomerase activity
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Biological Process:
acrosome reaction; carbohydrate metabolic process; fructose 6-phosphate metabolic process; fructose biosynthetic process; generation of precursor metabolites and energy; glucosamine catabolic process; glucosamine metabolic process; N-acetylglucosamine catabolic process; N-acetylglucosamine metabolic process; N-acetylneuraminate catabolic process; UDP-N-acetylglucosamine biosynthetic process
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Reference #:
O88958
(UniProtKB)
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Alt. Names/Synonyms: GlcN6P deaminase 1; Glucosamine-6-phosphate deaminase 1; Glucosamine-6-phosphate isomerase 1; glucose-6-phosphate isomerase; Gnp1; GNPDA; GNPDA 1; Gnpda1; Gnpi; GNPI1; KIAA0060; Oscillin
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Gene Symbols: Gnpda1
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Molecular weight:
32,549 Da
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Basal Isoelectric point:
6.13
Predict pI for various phosphorylation states
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