DYN1 a microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Concentrates within the presynaptic compartment and may participate in specialized neuronal functions such as rapid synaptic vesicle recycling. Part of a protein network that controls nucleation of actin from membranes. Contains one PH domain. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Motor; Vesicle
Chromosomal Location of Human Ortholog: 9q34.11
Cellular Component:  axon; chloroplast; cytoplasm; cytoplasmic vesicle; dendritic spine; dendritic spine head; Golgi apparatus; membrane; membrane coat; microtubule; microtubule cytoskeleton; myelin sheath; nucleoplasm; nucleus; peroxisome; photoreceptor inner segment; plasma membrane; postsynaptic density; postsynaptic endocytic zone membrane; postsynaptic membrane; synapse; synaptic vesicle
Molecular Function:  D2 dopamine receptor binding; GTP binding; GTPase activity; identical protein binding; microtubule binding; nitric-oxide synthase binding; protein binding; protein C-terminus binding; protein dimerization activity; protein kinase binding; SH3 domain binding
Biological Process:  adult locomotory behavior; chloroplast fission; clathrin-dependent endocytosis; endocytosis; endosome organization and biogenesis; ephrin receptor signaling pathway; G-protein coupled receptor internalization; organelle fission; peroxisome fission; positive regulation of synaptic vesicle endocytosis; postsynaptic neurotransmitter receptor internalization; protein tetramerization; receptor internalization; receptor-mediated endocytosis; regulation of synapse structure or activity; response to amyloid-beta; sensory perception of sound; synaptic transmission, GABAergic; synaptic vesicle budding from presynaptic endocytic zone membrane; toxin transport
Disease: Epileptic Encephalopathy, Early Infantile, 31
Reference #:  Q05193 (UniProtKB)
Alt. Names/Synonyms: DNM; DNM1; DYN1; dynamin 1; Dynamin-1
Gene Symbols: DNM1
Molecular weight: 97,408 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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