DYN1 a microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Concentrates within the presynaptic compartment and may participate in specialized neuronal functions such as rapid synaptic vesicle recycling. Part of a protein network that controls nucleation of actin from membranes. Contains one PH domain. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Motor; Vesicle
Chromosomal Location of Human Ortholog: 9q34.11
Cellular Component:  glutamatergic synapse; Golgi apparatus; membrane coat; microtubule; nucleoplasm; nucleus; photoreceptor inner segment; photoreceptor ribbon synapse; plasma membrane; presynaptic endocytic zone membrane; synaptic vesicle; varicosity
Molecular Function:  D2 dopamine receptor binding; GTP binding; identical protein binding; nitric-oxide synthase binding; protein binding; protein C-terminus binding; protein kinase binding; protein-containing complex binding; SH3 domain binding
Biological Process:  clathrin-dependent endocytosis; endocytosis; endosome organization; ephrin receptor signaling pathway; G protein-coupled receptor internalization; modulation of chemical synaptic transmission; positive regulation of synaptic vesicle endocytosis; receptor-mediated endocytosis; response to amyloid-beta; toxin transport
Disease: Epileptic Encephalopathy, Early Infantile, 31
Reference #:  Q05193 (UniProtKB)
Alt. Names/Synonyms: DNM; DNM1; DYN1; dynamin 1; Dynamin-1
Gene Symbols: DNM1
Molecular weight: 97,408 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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