DYN1 Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Motor; Vesicle
Chromosomal Location of Human Ortholog: 9q34.11
Cellular Component:  glutamatergic synapse; Golgi apparatus; membrane coat; microtubule; nucleoplasm; nucleus; photoreceptor inner segment; photoreceptor ribbon synapse; plasma membrane; presynaptic endocytic zone membrane; synaptic vesicle; varicosity
Molecular Function:  D2 dopamine receptor binding; GTP binding; identical protein binding; nitric-oxide synthase binding; protein binding; protein C-terminus binding; protein kinase binding; protein-containing complex binding; SH3 domain binding
Biological Process:  clathrin-dependent endocytosis; endocytosis; endosome organization; ephrin receptor signaling pathway; G protein-coupled receptor internalization; modulation of chemical synaptic transmission; positive regulation of synaptic vesicle endocytosis; receptor-mediated endocytosis; response to amyloid-beta; toxin transport
Disease: Epileptic Encephalopathy, Early Infantile, 31
Reference #:  Q05193 (UniProtKB)
Alt. Names/Synonyms: DNM; DNM1; DYN1; dynamin 1; Dynamin-1
Gene Symbols: DNM1
Molecular weight: 97,408 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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