VDAC2 Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective. Interacts with hexokinases. Expressed in all tissues examined. Belongs to the eukaryotic mitochondrial porin family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Channel, misc.; Membrane protein, integral; Mitochondrial
Chromosomal Location of Human Ortholog: 14 A3|14 11.91 cM
Cellular Component:  acrosomal vesicle; integral component of membrane; membrane; membrane raft; mitochondrial nucleoid; mitochondrial outer membrane; mitochondrion; pore complex; synaptic vesicle
Molecular Function:  nucleotide binding; porin activity; protein binding; voltage-gated anion channel activity
Biological Process:  anion transmembrane transport; anion transport; binding of sperm to zona pellucida; ion transport; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of protein polymerization; transmembrane transport
Reference #:  Q60930 (UniProtKB)
Alt. Names/Synonyms: mVDAC2; mVDAC6; OTTMUSP00000017619; Outer mitochondrial membrane protein porin 2; VDAC-2; VDAC-6; Vdac2; Vdac6; voltage-dependent anion channel 2; Voltage-dependent anion-selective channel protein 2; Voltage-dependent anion-selective channel protein 6
Gene Symbols: Vdac2
Molecular weight: 31,733 Da
Basal Isoelectric point: 7.44  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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VDAC2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene