VDAC2 Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. Belongs to the eukaryotic mitochondrial porin family. Expressed in all tissues examined. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, misc.; Membrane protein, integral; Mitochondrial
Chromosomal Location of Human Ortholog: 10q22.2
Cellular Component:  acrosomal vesicle; mitochondrial nucleoid; mitochondrion; pore complex; synaptic vesicle
Molecular Function:  nucleotide binding; porin activity; protein binding; voltage-gated anion channel activity
Biological Process:  anion transmembrane transport; anion transport; binding of sperm to zona pellucida; inorganic anion transport; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of protein polymerization
Reference #:  P45880 (UniProtKB)
Alt. Names/Synonyms: epididymis secretory sperm binding protein; FLJ23841; hVDAC2; Outer mitochondrial membrane protein porin 2; POR; VDAC-2; VDAC2; voltage dependent anion channel 2; voltage-dependent anion channel 2; Voltage-dependent anion-selective channel protein 2
Gene Symbols: VDAC2
Molecular weight: 31,566 Da
Basal Isoelectric point: 7.5  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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