SPT6 Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A. Belongs to the SPT6 family. Ubiquitously expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; RNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 11 B5|11 46.74 cM
Cellular Component:  nucleus; transcription elongation factor complex; transcriptionally active chromatin
Molecular Function:  DNA binding; histone binding; nucleic acid binding; nucleosome binding; protein binding
Biological Process:  blastocyst formation; chromatin maintenance; mRNA processing; mRNA transcription by RNA polymerase II; mRNA transport; negative regulation of histone H3-K27 methylation; nucleobase-containing compound metabolic process; nucleosome organization; positive regulation of transcription elongation from RNA polymerase II promoter; regulation of isotype switching; regulation of mRNA export from nucleus; regulation of mRNA processing; regulation of muscle cell differentiation; RNA splicing; transcription elongation from RNA polymerase II promoter
Reference #:  Q62383 (UniProtKB)
Alt. Names/Synonyms: 5131400N11Rik; AI132449; Kiaa0162; mKIAA0162; OTTMUSP00000000159; SPT6; SPT6, histone chaperone and transcription elongation factor; SPT6H; suppressor of Ty 6 homolog; suppressor of Ty 6 homolog (S. cerevisiae); Supt; Supt6; Supt6h; Transcription elongation factor SPT6
Gene Symbols: Supt6h
Molecular weight: 199,086 Da
Basal Isoelectric point: 4.83  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA