SH3BP1 GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration. Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions. Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment. It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells. 4 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; GAP; GAP, Rac/Rho
Chromosomal Location of mouse Ortholog: 15|15 E1
Cellular Component:  adherens junction; anchoring junction; bicellular tight junction; cell leading edge; cell projection; cytoplasm; cytosol; exocyst; intracellular anatomical structure; lamellipodium; nucleus; phagocytic cup
Molecular Function:  GTPase activator activity; semaphorin receptor binding; SH3 domain binding
Biological Process:  actin filament organization; cell junction assembly; cell migration; establishment of epithelial cell apical/basal polarity; filopodium assembly; negative regulation of small GTPase mediated signal transduction; phagocytosis; phagocytosis, engulfment; positive regulation of GTPase activity; regulation of actin cytoskeleton organization; regulation of actin filament depolymerization; regulation of blood vessel endothelial cell migration; regulation of Rac protein signal transduction; ruffle assembly; semaphorin-plexin signaling pathway; signal transduction
Reference #:  P55194 (UniProtKB)
Alt. Names/Synonyms: 3BP-; 3BP-1; 3bp1; OTTMUSP00000023077; SH3 domain-binding protein 1; SH3-domain binding protein 1; Sh3bp1
Gene Symbols: Sh3bp1
Molecular weight: 74,172 Da
Basal Isoelectric point: 6.15  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein