SH3BP1 Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; GAP; GAP, Rac/Rho
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component:  adherens junction; bicellular tight junction; cell leading edge; cytosol; lamellipodium; nucleus; phagocytic cup
Molecular Function:  GTPase activator activity; protein binding; semaphorin receptor binding; SH3 domain binding
Biological Process:  actin filament organization; cell junction assembly; cell migration; establishment of epithelial cell apical/basal polarity; filopodium assembly; negative regulation of small GTPase mediated signal transduction; phagocytosis, engulfment; positive regulation of GTPase activity; regulation of actin cytoskeleton organization; regulation of actin filament depolymerization; regulation of blood vessel endothelial cell migration; ruffle assembly; semaphorin-plexin signaling pathway
Reference #:  Q9Y3L3 (UniProtKB)
Alt. Names/Synonyms: 3BP-1; 3BP1; ARHGAP43; SH3 domain binding protein 1; SH3 domain-binding protein 1; SH3-domain binding protein 1; SH3BP1
Gene Symbols: SH3BP1
Molecular weight: 75,713 Da
Basal Isoelectric point: 6.33  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB