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PHB
Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging. Belongs to the prohibitin family. Widely expressed in different tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; Cell cycle regulation; Chaperone; Mitochondrial; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor |
| Chromosomal Location of mouse Ortholog: 11 59.01 cM|11 D |
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Cellular Component:
cell surface; cytoplasm; early endosome; extrinsic component of presynaptic active zone membrane; GABA-ergic synapse; glutamatergic synapse; membrane; mitochondrial inner membrane; mitochondrial outer membrane; mitochondrial prohibitin complex; mitochondrion; nucleoplasm; nucleus; plasma membrane; postsynaptic density; synapse
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Molecular Function:
complement component C3a binding; complement component C3b binding; enzyme binding; histone deacetylase binding; protein binding; protein heterodimerization activity; proteinase activated receptor binding; transcription corepressor activity
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Biological Process:
activation of phospholipase C activity; activation of protein kinase C activity; antiviral innate immune response; B cell activation; CD40 signaling pathway; cellular response to interleukin-6; DNA biosynthetic process; epigenetic regulation of gene expression; mitochondrion organization; modulation by host of viral RNA genome replication; negative regulation of androgen receptor signaling pathway; negative regulation of apoptotic process; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of DNA-templated transcription; negative regulation of ERK1 and ERK2 cascade; negative regulation of gene expression; negative regulation of glucocorticoid receptor signaling pathway; negative regulation of protein catabolic process; negative regulation of transcription by competitive promoter binding; negative regulation of transcription by RNA polymerase II; positive regulation of complement activation; positive regulation of DNA-templated transcription; positive regulation of ERK1 and ERK2 cascade; positive regulation of G protein-coupled receptor signaling pathway; positive regulation of gene expression; positive regulation of immunoglobulin production; positive regulation of interleukin-17 production; positive regulation of neuron apoptotic process; positive regulation of NIK/NF-kappaB signaling; positive regulation of protein kinase B signaling; positive regulation of smooth muscle cell proliferation; progesterone receptor signaling pathway; protein stabilization; regulation of DNA-templated transcription; RIG-I signaling pathway; T-helper 17 type immune response; viral entry into host cell
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Reference #:
P67778
(UniProtKB)
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Alt. Names/Synonyms: B-cell receptor-associated protein 32; BAP 32; BAP32; OTTMUSP00000001681; Phb; Phb1; Prohibitin; Prohibitin 1
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Gene Symbols: Phb1
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Molecular weight:
29,820 Da
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Basal Isoelectric point:
5.57
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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