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NUP50
Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling. Interacts with regulatory proteins of cell cycle progression including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B. Ubiquitous. Highest levels in testis, peripheral blood leukocytes and fetal liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear import; Nucleoporin |
| Chromosomal Location of mouse Ortholog: 15 E2|15 40.25 cM |
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Cellular Component:
nuclear envelope; nuclear membrane; nuclear pore; nucleoplasm; ribonucleoprotein complex
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Molecular Function:
protein binding
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Biological Process:
neural tube formation; nucleocytoplasmic transport; protein import into nucleus
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Reference #:
Q9JIH2
(UniProtKB)
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Alt. Names/Synonyms: 1700030K07Rik; 50 kDa nucleoporin; AI413123; Npap60; nuclear pore associated protein 60 kDa; Nuclear pore complex protein Nup50; Nuclear pore-associated protein 60 kDa-like; nucleoporin 50; Nucleoporin Nup50; nucleoprotein 50; Nup50
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Gene Symbols: Nup50
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Molecular weight:
49,485 Da
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Basal Isoelectric point:
5.94
Predict pI for various phosphorylation states
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