NNT The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland. In the C-terminal section; belongs to the PNT beta subunit family. Widely expressed with expression most readily detectable in adrenal, heart, kidney, thyroid and adipose tissues. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Oxidoreductase
Chromosomal Location of mouse Ortholog: 13 D2.3|13 67.21 cM
Cellular Component:  integral component of membrane; membrane; mitochondrion
Molecular Function:  NAD binding; NAD(P)+ transhydrogenase activity; NADP binding; oxidoreductase activity
Biological Process:  NADPH regeneration; oxidation-reduction process; proton transmembrane transport
Reference #:  Q61941 (UniProtKB)
Alt. Names/Synonyms: 4930423F13Rik; AI323702; BB168308; NAD(P) transhydrogenase, mitochondrial; Nicotinamide nucleotide transhydrogenase; Nnt; NNTM; Pyridine nucleotide transhydrogenase
Gene Symbols: Nnt
Molecular weight: 113,838 Da
Basal Isoelectric point: 7.53  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene