NNT The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland. In the C-terminal section; belongs to the PNT beta subunit family. Widely expressed with expression most readily detectable in adrenal, heart, kidney, thyroid and adipose tissues. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: 5p12
Cellular Component:  integral component of membrane; mitochondrial inner membrane; mitochondrial respiratory chain; mitochondrion
Molecular Function:  NAD binding; NAD(P)+ transhydrogenase (B-specific) activity; NADP binding
Biological Process:  cell redox homeostasis; cellular oxidant detoxification; negative regulation of apoptotic process; negative regulation of protein phosphorylation; oxidation-reduction process; oxygen homeostasis; positive regulation of hydrogen peroxide catabolic process; positive regulation of mitochondrial membrane potential; proton transmembrane transport; reactive oxygen species metabolic process; response to vitamin; tricarboxylic acid cycle
Disease: Glucocorticoid Deficiency 4
Reference #:  Q13423 (UniProtKB)
Alt. Names/Synonyms: GCCD4; MGC126502; MGC126503; NAD(P) transhydrogenase, mitochondrial; Nicotinamide nucleotide transhydrogenase; NNT; NNTM; Pyridine nucleotide transhydrogenase
Gene Symbols: NNT
Molecular weight: 113,896 Da
Basal Isoelectric point: 8.31  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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