NNT
The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland. In the C-terminal section; belongs to the PNT beta subunit family. Widely expressed with expression most readily detectable in adrenal, heart, kidney, thyroid and adipose tissues. Note: This description may include information from UniProtKB.
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Protein type: Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 1.6.1.2; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Oxidoreductase |
Chromosomal Location of human Ortholog: 5p12 |
Cellular Component:
mitochondrial inner membrane; mitochondrial respirasome; mitochondrion
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Molecular Function:
NAD binding; NAD(P)+ transhydrogenase (B-specific) activity; NAD(P)+ transhydrogenase activity; NADP binding
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Biological Process:
cell redox homeostasis; cellular oxidant detoxification; intracellular oxygen homeostasis; NADPH regeneration; negative regulation of apoptotic process; negative regulation of protein phosphorylation; positive regulation of hydrogen peroxide catabolic process; positive regulation of mitochondrial membrane potential; proton transmembrane transport; reactive oxygen species metabolic process; response to vitamin; tricarboxylic acid cycle
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Disease: Glucocorticoid Deficiency 4
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Reference #:
Q13423
(UniProtKB)
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Alt. Names/Synonyms: GCCD4; MGC126502; MGC126503; NAD(P) transhydrogenase, mitochondrial; Nicotinamide nucleotide transhydrogenase; NNT; NNTM; Pyridine nucleotide transhydrogenase
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Gene Symbols: NNT
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Molecular weight:
113,896 Da
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Basal Isoelectric point:
8.31
Predict pI for various phosphorylation states
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