LIG1 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Belongs to the ATP-dependent DNA ligase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; EC; Ligase
Chromosomal Location of human Ortholog: 19q13.33
Cellular Component:  intracellular membrane-bounded organelle; mitochondrion; nucleoplasm; nucleus
Molecular Function:  ATP binding; DNA binding; DNA ligase (ATP) activity; DNA ligase activity; metal ion binding; protein binding
Biological Process:  anatomical structure morphogenesis; base-excision repair; base-excision repair, gap-filling; cell division; DNA biosynthetic process; DNA ligation; DNA repair; lagging strand elongation; mismatch repair; Okazaki fragment processing involved in mitotic DNA replication; V(D)J recombination
Disease: Immunodeficiency 96
Reference #:  P18858 (UniProtKB)
Alt. Names/Synonyms: DNA ligase 1; DNA ligase I; DNLI1; LIG1; ligase I, DNA, ATP-dependent; MGC117397; MGC130025; Polydeoxyribonucleotide synthase [ATP] 1; polydeoxyribonucleotide synthase ATP 1
Gene Symbols: LIG1
Molecular weight: 101,736 Da
Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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