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LIG1
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Belongs to the ATP-dependent DNA ligase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA repair, damage; EC 6.5.1.1; Ligase |
| Chromosomal Location of Human Ortholog: 19q13.33 |
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Cellular Component:
intracellular membrane-bounded organelle; nucleoplasm
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Molecular Function:
ATP binding; DNA binding; DNA ligase activity; metal ion binding
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Biological Process:
anatomical structure morphogenesis; base-excision repair; cell division; DNA biosynthetic process; DNA ligation; DNA ligation involved in DNA repair; DNA repair; mismatch repair; nucleotide-excision repair, DNA gap filling; transcription-coupled nucleotide-excision repair
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Reference #:
P18858
(UniProtKB)
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Alt. Names/Synonyms: DNA ligase 1; DNA ligase I; DNLI1; LIG1; ligase I, DNA, ATP-dependent; MGC117397; MGC130025; Polydeoxyribonucleotide synthase [ATP] 1; polydeoxyribonucleotide synthase ATP 1
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Gene Symbols: LIG1
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Molecular weight:
101,736 Da
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Basal Isoelectric point:
5.49
Predict pI for various phosphorylation states
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