LIG1 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Belongs to the ATP-dependent DNA ligase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; EC 6.5.1.1; Ligase
Chromosomal Location of human Ortholog: 19q13.33
Cellular Component:  intracellular membrane-bounded organelle; mitochondrion; nucleoplasm; nucleus
Molecular Function:  ATP binding; DNA binding; DNA ligase (ATP) activity; DNA ligase activity; metal ion binding; protein binding
Biological Process:  anatomical structure morphogenesis; base-excision repair; base-excision repair, gap-filling; cell division; DNA biosynthetic process; DNA ligation; DNA repair; lagging strand elongation; mismatch repair; Okazaki fragment processing involved in mitotic DNA replication; V(D)J recombination
Disease: Immunodeficiency 96
Reference #:  P18858 (UniProtKB)
Alt. Names/Synonyms: DNA ligase 1; DNA ligase I; DNLI1; LIG1; ligase I, DNA, ATP-dependent; MGC117397; MGC130025; Polydeoxyribonucleotide synthase [ATP] 1; polydeoxyribonucleotide synthase ATP 1
Gene Symbols: LIG1
Molecular weight: 101,736 Da
Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states
Select Structure to View Below

LIG1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein