NME2 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not. Exhibits histidine protein kinase activity. Belongs to the NDK family. Isoform 1 and isoform 3 are ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Kinase, nucleoside diphosphate; Kinase, other; NDK family; Nuclear receptor co-regulator; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Other group
Chromosomal Location of Human Ortholog: 17q21.33
Cellular Component:  cell periphery; cytoplasm; cytosol; extracellular region; ficolin-1-rich granule lumen; intermediate filament; lamellipodium; mitochondrial membrane; perinuclear region of cytoplasm; ruffle; secretory granule lumen
Molecular Function:  ATP binding; DNA binding; enzyme binding; fatty acid binding; G-quadruplex DNA binding; GDP binding; intermediate filament binding; metal ion binding; nucleoside diphosphate kinase activity; protein binding; protein histidine kinase activity; protein serine/threonine kinase activity; transcription coactivator activity
Biological Process:  adenylate cyclase-activating G protein-coupled receptor signaling pathway; cell adhesion; cellular response to fatty acid; cellular response to glucose stimulus; cellular response to oxidative stress; CTP biosynthetic process; GTP biosynthetic process; integrin-mediated signaling pathway; negative regulation of apoptotic process; negative regulation of myeloid leukocyte differentiation; neutrophil degranulation; nucleobase-containing small molecule interconversion; nucleoside diphosphate phosphorylation; nucleoside triphosphate biosynthetic process; peptidyl-histidine phosphorylation; positive regulation of epithelial cell proliferation; positive regulation of keratinocyte differentiation; positive regulation of neuron projection development; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; protein autophosphorylation; protein complex oligomerization; regulation of epidermis development; response to growth hormone; UTP biosynthetic process
Reference #:  P22392 (UniProtKB)
Alt. Names/Synonyms: C-myc purine-binding transcription factor PUF; c-myc transcription factor; epididymis secretory sperm binding protein Li 155an; HEL-S-155an; Histidine protein kinase NDKB; MGC111212; NDK B; NDKB; NDP kinase B; NDPK-B; NDPKB; nm23-H2; NM23B; NME/NM23 nucleoside diphosphate kinase 2; NME1B; NME2; non-metastatic cells 2, protein (NM23) expressed in; non-metastatic cells 2, protein (NM23B) expressed in; Nucleoside diphosphate kinase B; nucleotide diphosphate kinase B; puf
Gene Symbols: NME2
Molecular weight: 17,298 Da
Basal Isoelectric point: 8.52  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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