MYO15A Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Highly expressed in pituitary. Also expressed at lower levels in adult brain, kidney, liver, lung, pancreas, placenta and skeletal muscle. Not expressed in brain. In the pituitary, highly expressed in anterior gland cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Motor
Chromosomal Location of mouse Ortholog: 11 B2|11 37.81 cM
Cellular Component:  cell projection; cytoplasm; cytoskeleton; myosin complex; stereocilium; stereocilium bundle
Molecular Function:  actin binding; ATP binding; motor activity; nucleotide binding; protein binding
Biological Process:  inner ear morphogenesis; locomotory behavior; sensory perception of sound
Reference #:  Q9QZZ4 (UniProtKB)
Alt. Names/Synonyms: Myo15; Myo15a; myosin XV; myosin XVA; Myosin-XV; OTTMUSP00000005997; OTTMUSP00000019141; sh-2; sh2; shaker 2; Unconventional myosin-15; Unconventional myosin-XV
Gene Symbols: Myo15a
Molecular weight: 395,622 Da
Basal Isoelectric point: 9.26  Predict pI for various phosphorylation states
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MYO15A

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene