MYO15A Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Highly expressed in pituitary. Also expressed at lower levels in adult brain, kidney, liver, lung, pancreas, placenta and skeletal muscle. Not expressed in brain. In the pituitary, highly expressed in anterior gland cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Motor
Chromosomal Location of human Ortholog: 17p11.2
Cellular Component:  actin cytoskeleton; actin-based cell projection; cytoplasm; myosin complex; stereocilium; vesicle
Molecular Function:  actin filament binding; ATP binding; calmodulin binding; microfilament motor activity
Biological Process:  actin filament organization; inner ear morphogenesis; locomotory behavior; response to light stimulus; sensory perception of sound; vesicle transport along actin filament
Disease: Deafness, Autosomal Recessive 3
Reference #:  Q9UKN7 (UniProtKB)
Alt. Names/Synonyms: DFNB3; DKFZp686N18198; FLJ17274; FLJ31311; MYO15; MYO15A; myosin XV; myosin XVA; Myosin-XV; Unconventional myosin-15; Unconventional myosin-XV
Gene Symbols: MYO15A
Molecular weight: 395,293 Da
Basal Isoelectric point: 9.26  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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