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MTTP
Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. Liver and small intestine. Also found in ovary, testis and kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Endoplasmic reticulum |
| Chromosomal Location of Human Ortholog: 3 G3|3 64.06 cM |
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Cellular Component:
basolateral plasma membrane; brush border membrane; endoplasmic reticulum; Golgi apparatus; microvillus membrane; receptor complex; rough endoplasmic reticulum; vesicle
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Molecular Function:
apolipoprotein binding; lipid binding; lipid transporter activity; phospholipid transporter activity; protein binding; protein heterodimerization activity
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Biological Process:
cholesterol homeostasis; cholesterol metabolic process; circadian rhythm; lipid metabolic process; lipid transport; lipoprotein metabolic process; lipoprotein transport; phospholipid transport; plasma lipoprotein particle assembly; protein lipidation; protein secretion; steroid metabolic process; triglyceride metabolic process; triglyceride transport
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Reference #:
O08601
(UniProtKB)
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Alt. Names/Synonyms: 1810043K16Rik; microsomal triglyceride transfer protein; microsomal triglyceride transfer protein B; Microsomal triglyceride transfer protein large subunit; microsomal triglyceride transfer protein, large subunit; Mtp; Mttp
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Gene Symbols: Mttp
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Molecular weight:
99,099 Da
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Basal Isoelectric point:
7.52
Predict pI for various phosphorylation states
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