MTTP Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. Liver and small intestine. Also found in ovary, testis and kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 3 G3|3 64.06 cM
Cellular Component:  basolateral plasma membrane; brush border membrane; endoplasmic reticulum; Golgi apparatus; microvillus membrane; receptor complex; rough endoplasmic reticulum; vesicle
Molecular Function:  apolipoprotein binding; lipid binding; lipid transporter activity; phospholipid transporter activity; protein binding; protein heterodimerization activity
Biological Process:  cholesterol homeostasis; cholesterol metabolic process; circadian rhythm; lipid metabolic process; lipid transport; lipoprotein metabolic process; lipoprotein transport; phospholipid transport; plasma lipoprotein particle assembly; protein lipidation; protein secretion; steroid metabolic process; triglyceride metabolic process; triglyceride transport
Reference #:  O08601 (UniProtKB)
Alt. Names/Synonyms: 1810043K16Rik; microsomal triglyceride transfer protein; microsomal triglyceride transfer protein B; Microsomal triglyceride transfer protein large subunit; microsomal triglyceride transfer protein, large subunit; Mtp; Mttp
Gene Symbols: Mttp
Molecular weight: 99,099 Da
Basal Isoelectric point: 7.52  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene