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MTTP
Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. Liver and small intestine. Also found in ovary, testis and kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Endoplasmic reticulum |
| Chromosomal Location of human Ortholog: 4q23 |
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Cellular Component:
basolateral plasma membrane; brush border membrane; cytosol; endoplasmic reticulum; endoplasmic reticulum lumen; Golgi apparatus; microvillus membrane; receptor complex; rough endoplasmic reticulum; vesicle
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Molecular Function:
apolipoprotein binding; ceramide 1-phosphate transfer activity; cholesterol transfer activity; lipid binding; lipid transporter activity; phosphatidylcholine transfer activity; phosphatidylethanolamine transfer activity; phospholipid transfer activity; phospholipid transporter activity; protein binding; protein heterodimerization activity; protein-containing complex binding; triglyceride transfer activity
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Biological Process:
ceramide 1-phosphate transport; cholesterol homeostasis; chylomicron assembly; circadian rhythm; establishment of localization in cell; intermembrane lipid transfer; lipid metabolic process; lipoprotein metabolic process; lipoprotein transport; low-density lipoprotein particle remodeling; phospholipid transport; plasma lipoprotein particle assembly; protein lipidation; protein secretion; response to calcium ion; sterol transport; triglyceride metabolic process; triglyceride transport; very-low-density lipoprotein particle assembly
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Disease: Abdominal Obesity-metabolic Syndrome 1; Abetalipoproteinemia
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Reference #:
P55157
(UniProtKB)
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Alt. Names/Synonyms: ABL; MGC149819; MGC149820; microsomal triglyceride transfer protein; microsomal triglyceride transfer protein (large polypeptide, 88kDa); Microsomal triglyceride transfer protein large subunit; MTP; MTTP
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Gene Symbols: MTTP
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Molecular weight:
99,351 Da
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Basal Isoelectric point:
8.61
Predict pI for various phosphorylation states
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