MTTP Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. Liver and small intestine. Also found in ovary, testis and kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 4q23
Cellular Component:  endoplasmic reticulum; endoplasmic reticulum lumen; receptor complex
Molecular Function:  lipid binding; lipid transporter activity; phospholipid transporter activity; protein binding; protein heterodimerization activity
Biological Process:  chylomicron assembly; lipid metabolic process; phospholipid transport; plasma lipoprotein particle assembly; protein secretion; triglyceride transport; very-low-density lipoprotein particle assembly
Disease: Abdominal Obesity-metabolic Syndrome 1; Abetalipoproteinemia
Reference #:  P55157 (UniProtKB)
Alt. Names/Synonyms: ABL; MGC149819; MGC149820; microsomal triglyceride transfer protein; microsomal triglyceride transfer protein (large polypeptide, 88kDa); Microsomal triglyceride transfer protein large subunit; MTP; MTTP
Gene Symbols: MTTP
Molecular weight: 99,351 Da
Basal Isoelectric point: 8.61  Predict pI for various phosphorylation states
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MTTP

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene