MTTP Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. Liver and small intestine. Also found in ovary, testis and kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Endoplasmic reticulum
Chromosomal Location of human Ortholog: 4q23
Cellular Component:  basolateral plasma membrane; brush border membrane; cytosol; endoplasmic reticulum; endoplasmic reticulum lumen; Golgi apparatus; microvillus membrane; receptor complex; rough endoplasmic reticulum; vesicle
Molecular Function:  apolipoprotein binding; ceramide 1-phosphate transfer activity; cholesterol transfer activity; lipid binding; lipid transporter activity; phosphatidylcholine transfer activity; phosphatidylethanolamine transfer activity; phospholipid transfer activity; phospholipid transporter activity; protein binding; protein heterodimerization activity; protein-containing complex binding; triglyceride transfer activity
Biological Process:  ceramide 1-phosphate transport; cholesterol homeostasis; chylomicron assembly; circadian rhythm; establishment of localization in cell; intermembrane lipid transfer; lipid metabolic process; lipoprotein metabolic process; lipoprotein transport; low-density lipoprotein particle remodeling; phospholipid transport; plasma lipoprotein particle assembly; protein lipidation; protein secretion; response to calcium ion; sterol transport; triglyceride metabolic process; triglyceride transport; very-low-density lipoprotein particle assembly
Disease: Abdominal Obesity-metabolic Syndrome 1; Abetalipoproteinemia
Reference #:  P55157 (UniProtKB)
Alt. Names/Synonyms: ABL; MGC149819; MGC149820; microsomal triglyceride transfer protein; microsomal triglyceride transfer protein (large polypeptide, 88kDa); Microsomal triglyceride transfer protein large subunit; MTP; MTTP
Gene Symbols: MTTP
Molecular weight: 99,351 Da
Basal Isoelectric point: 8.61  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene