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MTTP
Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. Liver and small intestine. Also found in ovary, testis and kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Endoplasmic reticulum |
| Chromosomal Location of Human Ortholog: 4q23 |
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Cellular Component:
endoplasmic reticulum; endoplasmic reticulum lumen; receptor complex
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Molecular Function:
lipid binding; lipid transporter activity; phospholipid transporter activity; protein binding; protein heterodimerization activity
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Biological Process:
chylomicron assembly; lipid metabolic process; phospholipid transport; plasma lipoprotein particle assembly; protein secretion; triglyceride transport; very-low-density lipoprotein particle assembly
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Disease: Abdominal Obesity-metabolic Syndrome 1; Abetalipoproteinemia
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Reference #:
P55157
(UniProtKB)
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Alt. Names/Synonyms: ABL; MGC149819; MGC149820; microsomal triglyceride transfer protein; microsomal triglyceride transfer protein (large polypeptide, 88kDa); Microsomal triglyceride transfer protein large subunit; MTP; MTTP
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Gene Symbols: MTTP
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Molecular weight:
99,351 Da
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Basal Isoelectric point:
8.61
Predict pI for various phosphorylation states
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