MTHFD2 Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency. Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - glyoxylate and dicarboxylate; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC; EC; Hydrolase; Mitochondrial; Oxidoreductase
Chromosomal Location of mouse Ortholog: 6 C3|6 35.94 cM
Cellular Component: 
Molecular Function:  catalytic activity; hydrolase activity; magnesium ion binding; methenyltetrahydrofolate cyclohydrolase activity; methylenetetrahydrofolate dehydrogenase (NAD+) activity; methylenetetrahydrofolate dehydrogenase (NADP+) activity; oxidoreductase activity; phosphate ion binding
Biological Process:  metabolic process; one-carbon metabolic process; oxidation-reduction process; tetrahydrofolate interconversion; tetrahydrofolate metabolic process
Reference #:  P18155 (UniProtKB)
Alt. Names/Synonyms: AW558851; Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Methenyltetrahydrofolate cyclohydrolase; methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase; MTDC; Mthfd2; NAD-dependent methylenetetrahydrofolate dehydrogenase; NMDM; Nmdmc; OTTMUSP00000026807
Gene Symbols: Mthfd2
Molecular weight: 37,863 Da
Basal Isoelectric point: 8.98  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene