MTHFD2 a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009]
Protein type: Carbohydrate Metabolism - glyoxylate and dicarboxylate; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC; EC; Hydrolase; Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: 6 C3|6 35.94 cM
Cellular Component: 
Molecular Function:  catalytic activity; hydrolase activity; magnesium ion binding; methenyltetrahydrofolate cyclohydrolase activity; methylenetetrahydrofolate dehydrogenase (NAD+) activity; methylenetetrahydrofolate dehydrogenase (NADP+) activity; oxidoreductase activity; phosphate ion binding
Biological Process:  metabolic process; one-carbon metabolic process; oxidation-reduction process; tetrahydrofolate interconversion; tetrahydrofolate metabolic process
Reference #:  P18155 (UniProtKB)
Alt. Names/Synonyms: AW558851; Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Methenyltetrahydrofolate cyclohydrolase; methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase; MTDC; Mthfd2; NAD-dependent methylenetetrahydrofolate dehydrogenase; Nmdmc; OTTMUSP00000026807
Gene Symbols: Mthfd2
Molecular weight: 37,863 Da
Basal Isoelectric point: 8.98  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene