MSH2 Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Recruits DNA helicase MCM9 to chromatin which unwinds the mismatch containg DNA strand. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-- Belongs to the DNA mismatch repair MutS family. Ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Tumor suppressor
Chromosomal Location of Human Ortholog: 17 E4|17 57.87 cM
Cellular Component:  chromosome; mismatch repair complex; MutSalpha complex; MutSbeta complex; nucleus
Molecular Function:  ATP binding; ATPase activity; centromeric DNA binding; chromatin binding; damaged DNA binding; DNA binding; DNA-dependent ATPase activity; double-strand/single-strand DNA junction binding; enzyme binding; guanine/thymine mispair binding; mismatched DNA binding; nucleotide binding; protein C-terminus binding; protein homodimerization activity; protein kinase binding
Biological Process:  B cell differentiation; B cell mediated immunity; cell cycle; cell cycle arrest; cellular response to DNA damage stimulus; determination of adult lifespan; DNA recombination; DNA repair; double-strand break repair; germ cell development; in utero embryonic development; intra-S DNA damage checkpoint; intrinsic apoptotic signaling pathway in response to DNA damage; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; isotype switching; maintenance of DNA repeat elements; male gonad development; mismatch repair; negative regulation of DNA recombination; negative regulation of neuron apoptotic process; oxidative phosphorylation; positive regulation of helicase activity; positive regulation of isotype switching to IgA isotypes; positive regulation of isotype switching to IgG isotypes; postreplication repair; protein localization to chromatin; response to UV-B; response to X-ray; somatic hypermutation of immunoglobulin genes; somatic recombination of immunoglobulin gene segments; somatic recombination of immunoglobulin genes involved in immune response
Reference #:  P43247 (UniProtKB)
Alt. Names/Synonyms: AI788990; DNA mismatch repair protein Msh2; Msh2; mutS homolog 2 (E. coli); MutS protein homolog 2
Gene Symbols: Msh2
Molecular weight: 104,151 Da
Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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MSH2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene