HSPA9B Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. Belongs to the heat shock protein 70 family. Note: This description may include information from UniProtKB.
Protein type: Chaperone; Heat shock protein; Nucleolus
Chromosomal Location of Human Ortholog: 5q31.2
Cellular Component:  mitochondrial matrix; mitochondrial nucleoid; mitochondrion; nucleolus
Molecular Function:  protein binding; ubiquitin protein ligase binding; unfolded protein binding
Biological Process:  erythrocyte differentiation; interleukin-12-mediated signaling pathway; iron-sulfur cluster assembly; negative regulation of apoptotic process; negative regulation of erythrocyte differentiation; negative regulation of hematopoietic stem cell differentiation; protein export from nucleus; regulation of erythrocyte differentiation
Disease: Anemia, Sideroblastic, 4; Even-plus Syndrome
Reference #:  P38646 (UniProtKB)
Alt. Names/Synonyms: 75 kDa glucose regulated protein; 75 kDa glucose-regulated protein; CSA; GRP-75; GRP75; Heat shock 70 kDa protein 9; heat shock 70kD protein 9; heat shock 70kD protein 9B; heat shock 70kDa protein 9; heat shock 70kDa protein 9 (mortalin); HSPA9; HSPA9B; MGC4500; Mortalin; mortalin, perinuclear; mortalin-2; MOT; mot-2; MOT2; MTHSP75; p66-mortalin; PBP74; Peptide-binding protein 74; Stress-70 protein, mitochondrial
Gene Symbols: HSPA9
Molecular weight: 73,680 Da
Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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HSPA9B

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein