HMGB3 Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor. Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling. Belongs to the HMGB family. Expressed predominantly in placenta. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of mouse Ortholog: X|X A7.3
Cellular Component:  chromosome; cytoplasm; nucleus
Molecular Function:  DNA binding; DNA binding, bending; RNA binding
Biological Process:  immune system process; innate immune response; negative regulation of B cell differentiation; negative regulation of myeloid cell differentiation; regulation of transcription by RNA polymerase II
Reference #:  O54879 (UniProtKB)
Alt. Names/Synonyms: high mobility group box 3; High mobility group protein 2a; High mobility group protein 4; High mobility group protein B3; high mobilty group protein 2A; high-mobility group protein 4; HMG-2a; HMG-4; Hmg2; Hmg2a; Hmg4; Hmgb3; OTTMUSP00000019352; OTTMUSP00000019353; OTTMUSP00000019354; OTTMUSP00000019355
Gene Symbols: Hmgb3
Molecular weight: 23,010 Da
Basal Isoelectric point: 8.48  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein